This information is intended exclusively for healthcare professionals empowered to prescribe or dispense medicines, specialized training is necessary for its correct interpretation.
Specifically, UCB indicates, the most frequent adverse events recorded (≥ 5%) with this drug have been somnolence (15.2%), dizziness (11.2%), headache (9.6%) and fatigue (8.7%). Trials with this drug have included more than 3,000 people.
Toledo M, Whitesides J, Schiemann J, et al. Safety, tolerability, and seizure control during long-term treatment with adjunctive brivaracetam for partial-onset seizures. Epilepsia. 201607;57(7):1139-1151.
You may have thoughts of suicide while taking this medicine. Your doctor should check your progress during regular visits. Your family or caregivers should also be alert to changes in your mood or symptoms.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medication exactly as directed.
Do not stop using brivaracetam suddenly, even if you feel fine. Stopping suddenly may cause serious medical problems or increase seizures. Follow your doctor’s instructions on how to gradually lower your dose.
Use all seizure medicines as directed. Do not change your dose or dosing schedule without your doctor’s advice. Tell your doctor if any of your medicines seem to have stopped working.
This list does not mention all side effects and others may occur. Call your doctor for medical advice about side effects. You can report side effects by calling the FDA at 1-800-FDA-1088.
Brivaracetam 100 mg
This Lexicomp® information explains what you need to know about this medicine, including what it is used for, how to take it, its side effects, and when to call your health care provider.
WARNING/CAUTION: Although very rare, some people may experience very serious, life-threatening side effects from taking a medicine. If you experience any of the following signs or symptoms that may be related to a very serious side effect, tell your doctor or seek medical attention immediately:
These are not all the side effects that could occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
Brivaracetam 50 mg
Brivaracetam solution for injection and infusion is an alternative for patients in whom oral administration is temporarily not feasible. There is no experience with intravenous administration of brivaracetam twice daily for periods longer than 4 days.
Treatment with brivaracetam can be initiated by both intravenous and oral administration. When switching from oral to intravenous administration or vice versa, the total daily dose and frequency of administration should be maintained.
No dose adjustment is required in patients with renal impairment (see section 5.2). Brivaracetam is not recommended in patients with end-stage renal disease undergoing dialysis due to lack of data.
Therefore, patients should be monitored for signs of suicidal thoughts and behavior and appropriate treatment should be considered. Patients (and their caregivers) should be advised to consult their physician if signs of suicidal thoughts or behavior appear. See also section 4.8, Pediatric population.